EPA Science Inventory

Cognitive Function Related to Environmental Exposure to Manganese

Citation:

Bowler, R., V. Gocheva, E. Schimbor, C. Beseler, M. Colledge, F. Du, H. Roels, G. Bollweg, AND D. Lobdell. Cognitive Function Related to Environmental Exposure to Manganese. Presented at Internatioal Neuropsychological Society meeting, Seattle, WA, February 12 - 15, 2014.

Description:

Background: The towns of Marietta and East Liverpool (EL), Ohio, have been identified as having elevated manganese (Mn) in air due to industrial pollution. Objectives: To evaluate relationships between environmental Mn (Mn-air) exposure and distance from the source and cognitive function in residents of two Ohio towns. Methods: Data were obtained from an EPA-sponsored study comparing two towns exposed to Mn-air (Marietta and EL). A cross-sectional design was used. The same inclusion/exclusion criteria and procedures were applied in the two towns. A neuropsychological screening test battery was administered to study participants (EL=86, Marietta=100) which included Stroop Color Word Test, Animal Naming, Auditory Consonant Trigrams (ACT) and Rey-O. To estimate Mn-air, U.S.EPA’s AERMOD dispersion model was used. Distance from source was calculated based on participants’ residential address and air miles from industrial facility emitting Mn-air. A binary logistic regression model controlling for annual household income was used to examine distance from source and neuropsychological outcomes Results: There were no age, sex, or employment status differences between the two towns. Years education was lower in EL (mean (M)=12.9) than Marietta (M=14.6) and years residency in town were higher in EL (M=47.0) than Marietta (M=36.1). EL participants resided closer to the Mn source than Marietta (M=1.12 vs M=4.75 air miles). Mn-air concentrations were higher in EL (M=0.269 μg/m3; range 0.10 to 23.0 µg/m3) than Marietta (M=0.184 μg/m3; range 0.04 to 0.96 µg/m3). There were significant town differences on tests of category fluency, immediate memory, and speed of word reading; the EL group had the lowest scores. Closer distance to the source significantly increased the odds of impairment (<2nd%) on ACT 9’ delay [OR=1.26, 95% CI: 1.02-1.55, p=.032], on ACT 18’ delay [OR=1.44, 95% CI: 1.11-1.87, p=.006], as well as on Rey-O copy raw score [OR=1.27, 95% CI: 1.01-1.61, p=.043]. Conclusions: Increased risk of impairment in delayed memory with distraction and visuospatial/executive function were related to residing closer to the Mn source. Environmental exposures are low compared to occupational exposures and small positive findings may be possible early effects of Mn. This abstract does not necessarily reflect EPA policy.

Purpose/Objective:

Two Ohio communities were identified with elevated measured concentrations of ambient air-Mn, one of which has the highest concentrations of measured air-Mn reported to the United States Environmental Protection Agency (U.S.EPA) Air Quality System (AQS) database (U.S.EPA, 2012a). Air-Mn in one community (Marietta) is predominantly released from a large ferro-alloy smelting plant (Eramet, Inc.) while in the other community (East Liverpool) it is released during the offloading, grinding (for resizing), packaging, and storage of Mn-containing ore products at a metals storage and packaging facility (S.H. Bell Company. The objective of this study was to evaluate relationships between environmental Mn (Mn-air) exposure and distance from the source and cognitive function in residents of two Ohio towns.

URLs/Downloads:

COGNITIVE ABSTRACT_CLEARANCE.DOCX

Record Details:

Record Type: DOCUMENT (PRESENTATION/ABSTRACT)
Completion Date: 03/12/2014
Record Last Revised: 03/12/2014
Record Created: 03/12/2014
Record Released: 03/12/2014
OMB Category: Other
Record ID: 270695

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

ENVIRONMENTAL PUBLIC HEALTH DIVISION

EPIDEMIOLOGY BRANCH