EPA Science Inventory

Synthesis of unnatural amino acids via microwave-assisted regio-selective one-pot multi-component reactions of sulfamidates

Citation:

Baig, N. AND R. Varma. Synthesis of unnatural amino acids via microwave-assisted regio-selective one-pot multi-component reactions of sulfamidates. Current Organic Chemistry. Bentham Science Publishers, Ltd., Oak Park, IL, 17(20):2323-2331, (2013).

Description:

Synthesis of triazole-based unnatural amino acids, triazole bisaminoacids and β-amino triazole has been described via stereo and regioselective one-pot multi-component reaction of sulfamidates, sodium azide, and alkynes under MW irradiation conditions. The developed method is applicable to a broad substrate scope and has significant potential for the synthesis of triazole modified unnatural amino acids.

Purpose/Objective:

Submitted to the Royal Society of chemistry (RSC) journal, Organic and Biomolecular Chemistry

URLs/Downloads:

http://dx.doi.org/10.2174/13852728113179990047   Exit

http://www.ingentaconnect.com/content/ben/coc/2013/00000017/0000   Exit

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 10/01/2013
Completion Date: 10/01/2013
Record Last Revised: 03/31/2014
Record Created: 02/19/2014
Record Released: 02/19/2014
OMB Category: Other
Record ID: 269159

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL RISK MANAGEMENT RESEARCH LABORATORY

SUSTAINABLE TECHNOLOGY DIVISION

CLEAN PROCESSES BRANCH