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Benchmark Dose Modeling
Zhao, J. Benchmark Dose Modeling. Presented at Society of Toxicology 2014, Phoenix, AZ, March 23 - 27, 2014.
Finite doses are employed in experimental toxicology studies. Under the traditional methodology, the point of departure (POD) value for low dose extrapolation is identified as one of these doses. Dose spacing necessarily precludes a more accurate description of the POD value. Benchmark Dose (BMD) modeling offers a distinct advantage in establishing the POD value in that it provides a robust statistical evaluation including results from each dose tested. This lecture will present the salient features of BMD guidance and will use examples from completed risk assessments to illustrate its application and advantages over the traditional approach.
Provide continue education training on risk assessment at a professional society annual meeting.
Record Details:Record Type: DOCUMENT (PRESENTATION/SLIDE)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT