EPA Science Inventory

Benchmark Dose Modeling

Citation:

Zhao, J. Benchmark Dose Modeling. Presented at Society of Toxicology 2014, Phoenix, AZ, March 23 - 27, 2014.

Description:

Finite doses are employed in experimental toxicology studies. Under the traditional methodology, the point of departure (POD) value for low dose extrapolation is identified as one of these doses. Dose spacing necessarily precludes a more accurate description of the POD value. Benchmark Dose (BMD) modeling offers a distinct advantage in establishing the POD value in that it provides a robust statistical evaluation including results from each dose tested. This lecture will present the salient features of BMD guidance and will use examples from completed risk assessments to illustrate its application and advantages over the traditional approach.

Purpose/Objective:

Provide continue education training on risk assessment at a professional society annual meeting.

URLs/Downloads:

JZHAOBMD.PPT

Record Details:

Record Type: DOCUMENT (PRESENTATION/SLIDE)
Completion Date: 02/13/2014
Record Last Revised: 02/13/2014
Record Created: 02/13/2014
Record Released: 02/13/2014
OMB Category: Other
Record ID: 268764

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT