EPA Science Inventory

Solvent-free and catalyst-free chemistry: A benign pathway to sustainability

Citation:

Gawande, M., V. Bonifacio, R. Luque, P. Branco, AND R. Varma. Solvent-free and catalyst-free chemistry: A benign pathway to sustainability. ChemSusChem. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 7(1):24-44, (2014).

Description:

In the past decade, alternative benign organic methodologies have become an imperative part of organic syntheses and novel chemical reactions. The various new and innovative sustainable organic reactions and methodologies using no solvents or catalysts and employing alternative energy inputs such as microwave (MW), sonication, conventional and room temperature heating conditions, mechanochemical mixing, and high speed ball milling are discussed here in detail. Environmentally benign and pharmaceutical important reactions such as multicomponent reactions, condensation reactions, Michael addition reactions, ring opening of epoxides, oxidation and other significant organic reactions are discussed. An overview of benign reactions via solvent-free and catalyst-free (SF-CF) chemistry and a critical perspective on emerging synergies between SF-CF organic reactions are discussed.

Purpose/Objective:

Submitted to the American Chemical Society (ACS) Journal, Chemical Reviews

URLs/Downloads:

http://dx.doi.org/10.1002/cssc.201300485   Exit

Website   Exit

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 01/01/2014
Completion Date: 01/01/2014
Record Last Revised: 03/31/2014
Record Created: 01/28/2014
Record Released: 01/28/2014
OMB Category: Other
Record ID: 267584

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL RISK MANAGEMENT RESEARCH LABORATORY

SUSTAINABLE TECHNOLOGY DIVISION

CLEAN PROCESSES BRANCH