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Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology (External Review Draft)
[UPDATE] EPA has extended the public comment period 60 more days. At the request of the American Chemistry Council, the public comment deadline is extended to January 13, 2014. [Federal Register Notice November 13, 2013]
EPA announces the release of the draft report, Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology (External Review Draft) in a September 30, 2013 Federal Register Notice. This draft report is provided for public viewing and comment. Public comments received on the draft report within 45 days after the release of the FRN will be considered by EPA in their revisions. The deadline for comments is November 14, 2013.
Citation:
U.S. EPA. Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-13/214A, 2013.
Impact/Purpose:
This document presents the results and lessons learned from the prototypes/case studies for use of molecular, computational, and systems biology data in risk assessment. The prototype results demonstrated proof of concept for an integrated approach to incorporating molecular, computational, and systems biology data in risk assessment and considered various data types for specific assessment purposes. The lessons learned from this project suggested research needs and near- and longer-term implications of incorporating molecular, computational, and systems biology data in risk assessment.
Description:
EPA is releasing a draft report "Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology" that explores how new molecular, computational and systems biology data and approaches (together called "NexGen") could better inform risk assessment. The report summarizes the state of the science and provides prototypes, which are case studies that use available NexGen information. This draft report will be available for public review and comment and will undergo independent external peer review.
URLs/Downloads:
Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology (External Review Draft) (PDF, 142 pp, 4442 KB, about PDF)NAS Emerging Sciences Web site
NAS Systems Biology Informed Risk Assessment
2011 NexGen Public Dialogue Conference presentation videos, slides, and draft summary report
EPA’s NexGen Program
EPA’s Chemical Safety Research Page
EPA's Computational Toxicology Research Program
NAS's Emerging Science for Environmental Health Decisions
Agency for Toxic Substances and Disease Registry (ATSDR)
California Environmental Protection Agency Home
CDC National Center for Environmental Health (NCEH)
FR Notice: Nov 13, 2013
FR Notice: Sep 30, 2013