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PEROXIDES AND MACROPHAGES IN THE TOXICITY OF FINE PARTICULATE MATTER IN RATS
Impact/Purpose:
Epidemiologic studies have established an association between short-term increases in ambient levels of particulate matter and increases in morbidity and mortality. The biological mechanisms underlying these associations are not well understood, however. Dr Debra Laskin of Rutgers University and colleagues will test the hypothesis that oxidants in ambient air, such as hydrogen peroxide, may be transported by fine particulate matter into the lungs and thus contribute to lung tissue injury. The investigators’ believe that this research will provide insight into transportation of volatile compounds into the lung and provide valuable information on the health effects of particles and peroxides.
Description:
The investigators will test the hypothesis that oxidants in ambient air, such as hydrogen peroxide, may be transported by fine particulate matter into the lungs and thus contribute to lung tissue injury.