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IRIS Toxicological Review of Trimethylbenzenes (Revised External Review Draft)
EPA's Science Advisory Board (SAB) Staff Office has announced two meetings for the SAB Chemical Assessment Advisory Committee (CAAC), augmented for the review of the draft IRIS assessment of trimethylbenzenes (CAAC-Trimethylbenzenes panel). The first meeting is a public teleconference scheduled for May 22, 2014. The second is a face-to face panel meeting scheduled for June 17-19, 2014 in Arlington, VA. Additional information about participation in the external peer review meetings, including how to provide comments to the SAB, are now available on the SAB review of trimethylbenzenes website and via the Federal Register.
Citation:
U.S. EPA. IRIS Toxicological Review of Trimethylbenzenes (Revised External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-13/171, 2013.
Impact/Purpose:
EPA is reassessing its IRIS toxicological review of Trimethylbenzenes (1,2,3-;1,2,4-;1,3,5-). This trimethylbenzene reassessment consists of an oral reference dose (RfD), an inhalation reference concentration (RfC), an inhalation unit risk (IUR) and a cancer weight of evidence descriptor. This is the first assessment developing an RfC or IUR for this compound. This assessment is intended to provide human health data to support agency regulatory decisions.
Description:
In August 2013, EPA submitted a revised draft IRIS assessment of trimethylbenzenes to the agency's Science Advisory Board (SAB) and posted this draft on the IRIS website. EPA had previously released a draft of the assessment for public comment, held a public meeting about the draft, and then revised it based on the comments received. The SAB CAAC-Trimethylbenzenes panel will review this draft assessment. Details about the meeting dates, times, and location are available via the Federal Register Notice posted on March 25, 2014. The SAB provided information on how the public can participate in the external peer review meetings, as well as instructions about how to provide comments to the SAB in the notice. Additional information on the "SAB review of trimethylbenzenes" is on the SAB website.
Report Information: The Toxicological Review of Trimethylbenzenes was originally released for a 60-day public comment period on June 29, 2012. [Federal Register Notice Jun 29, 2012] EPA revised the toxicological review in response to the public comments received. EPA has released the revised external review draft trimethylbenzenes assessment and the SAB CAAC is conducting a peer review of the scientific basis supporting the assessment that will appear in the Integrated Risk Information System (IRIS) database. Information regarding the peer review can be found at the "SAB review of trimethylbenzene" website.
URLs/Downloads:
IRIS Toxicological Review of Trimethylbenzenes (Revised External Review Draft) (Aug 2013) (PDF, 161 pp, 2064 KB, about PDF)Supplemental Information for Trimethylbenzenes (Aug 2013) (PDF, 284 pp, 10060 KB, about PDF)
Draft NCEA Charge for Reviewers (Aug 2013) - Revised Mar 2014 (PDF, 7 pp, 202 KB, about PDF)
SAB Project Page for Trimethylbenzenes
SAB Teleconference Meeting Agenda - May 22, 2014
Final Peer Review Report of the 1995 Koch Industries Study Report (PDF, 23 pp, 377 KB, about PDF)
SAB FR Notice: Mar 25, 2014
FR Notice: June 29, 2012
Peer Review Plan (PDF, NA pp, 33 KB, about PDF)
REVIEW OF THE IRIS DRAFT TOXICOLOGICAL REVIEW OF TRIMETHYLBENZENES
AGENCY RESPONSE