You are here:
New Approaches in International Guidelines for Genetic Toxicology Assays: Latest Updates on OECD Guidelines
Citation:
Thybaud, V., J. van Benthem, N. Delrue, G. Douglas, E. Lorge, M. Moore, R. Schoeny, AND T. Singer. New Approaches in International Guidelines for Genetic Toxicology Assays: Latest Updates on OECD Guidelines. Presented at Society of Toxicology, March 10 - 14, 2013.
Impact/Purpose:
This is the abstract of a presentation given at the 2013 meeting of the Society of Toxicology. OECD test guidelines are used globally. There is no description of or conflict with U.S. EPA policy.
Description:
In March 2010, the 22nd meeting of the Working Group of National Coordinators of the OECD Test Guidelines Programme (WNT) approved a project for updating the Test Guidelines on genotoxicity, with Canada, the Netherlands, France and the USA identified as lead countries for this work. An Expert Working Group (EWG) comprised of international experts was established and has since met twice. The EWG has recommended the deletion of several Test Guidelines, including the assays conducted in yeast and Drosophila. The EWG is currently working on revisions to the in vitro Test Guidelines for the micronucleus test (TG487), chromosomal aberration test (TG473) and gene mutation test (TG476), as well as the in vivo assays for the mammalian erythrocyte micronucleus test (TG474), the mammalian bone marrow chromosomal aberration test (TG475), the dominant lethal test (TG478) and the spermatogonial chromosomal aberration assay (TG483). A new guideline dedicated to the thymidine kinase locus is also under development. In addition, an update has been initiated of the Introduction Document to the genetic toxicology test guidelines, which is intended to provide succinct and useful guidance to guideline users. The purpose of the presentation at the SOT meeting will be to provide information on the status of the revision process and its main accomplishments to date. The opinions in this abstract are those of the authors and do not represent the policies of the U.S. EPA.