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In Utero Phthalate Effects in the Female Rat: A Model for MRKH Syndrome
Citation:
Hannas, B., K. Howdeshell, J. Furr, AND E. Gray. In Utero Phthalate Effects in the Female Rat: A Model for MRKH Syndrome. Presented at Triangle Consortium for Reproductive Biology, Durham, NC, March 01 - 02, 2013.
Impact/Purpose:
This abstract will be presented at the Triangle Consortium for Reproductive Biology, Duke University , Durham, NC, March 1-2, 2013
Description:
Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is characterized by uterine and vaginal canal aplasia in normal karyotype human females and is a syndrome with poorly define etiology. Reproductive toxicity of phthlate esters (PEs) occurs in rat offspring exposed in utero. a phenomenon that is better studied in male offspring than females. The current study report; female reproductive tract malformations in the Sprague Dawley rat similar to those characteristic of MRKH syndrome, following in utero exposure to a mixture of 5 PEs. We determined that females are “2-fold less sensitive to the effects of the 5-PE mixture than male for reproductive tract malformations. We were not fully successful in defining the critical exposure period for females; however, incidence of malformations was 88% following dosing from GD 8-19 versus 22% and 0% for GD8-13 and GD14-19, respectively. Overall, this study provides valuable information regarding female vulnerability to in utero phtha late exposure ani further characterizes a potential model for the human MRKH syndrome. Disclaimer: This abstract does not necessarily reflect EPA policy.