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Greener Synthesis of N-Heterocycles via Sustainable Applications of Nano-Catalysts
Citation:
Varma, R. Greener Synthesis of N-Heterocycles via Sustainable Applications of Nano-Catalysts. Presented at International Conference on Chemistry of Nitrogen Containing Heterocycles, Kharkiv, UKRAINE, November 12 - 16, 2012.
Impact/Purpose:
to be presented as an invited plenary lecture at the International Conference on Chemistry of Nitrogen Containing Heterocycles, Kharkiv, Ukraine Nov. 12-16, 2012.
Description:
A brief historic account of reactions involving microwave (MW) exposure of neat reactants or catalysis by mineral surfaces, such as alumina, silica, clay, or their ‘doped’ versions, for the rapid one-pot assembly of heterocyclic compounds from in situ generated reactive intermediates such as using hypervalent iodine reagents will be described; the approach can be adapted for parallel synthesis in multicomponent reactions. The eco-friendly nucleophilic substitution chemistry in water to generate cyclic amines via double N-alkylation of primary amines or hydrazines by dihalides or tosylates enables the greener synthesis of a range of pharmaceutically active heterocycles. MW aqueous hydrothermal process has been used to generate magnetic nanoferrites and micro-pine structured catalysts from readily available metal salts. Sustainable route to nanoparticles using glutathione, sugar, polyphenols from winery waste and their applications in catalysis to assemble nitrogen heterocycles will be highlighted. The approach attempts to fulfill most of the Green Chemistry Principles in a comprehensive manner and aims to create sustainable functional chemicals that may find large scale use with extreme level of waste minimization