Citation:

Reif, D., M. Sypa, E. Lock, F. Wright, A. Wilson, T. Cathey, R. Judson, AND I. Rusyn. ToxPi GUI: An interactive visualization tool for transparent integration of data from diverse sources of evidence. BIOINFORMATICS. Oxford University Press, Cary, NC, 29(3):402-403, (2013).

Impact/Purpose:

The current applications of ToxPi have focused on prioritization of chemicals; however, any units of categorization with varied output profiles could be used. Thus, the application may be used, for example, to compare groups of human or animal subjects across clinical, molecular, behavioral, and environmental data,facilitating additional novel integrated analyses and displays.

Description:

Motivation: Scientists and regulators are often faced with complex decisions, where use of scarce resources must be prioritized using collections of diverse information. The Toxicological Prioritization Index (ToxPi™) was developed to enable integration of multiple sources of evidence on exposure and/or safety, transformed into transparent, visual rankings to facilitate decision-making. The rankings and associated graphical profiles can be used to prioritize resources in various decision contexts, such as testing chemical toxicity or assessing similarity of predicted compound bioactivity profiles. The amount and types of information available to decision makers are increasing exponentially, while the complex decisions must rely on specialized domain knowledge across multiple criteria of varying importance. Thus the ToxPi bridges a gap, combining rigorous ag-gregation of evidence with ease of communication to diverse stakeholders. Solution: An interactive ToxPi graphical user interface (GUI) application has been implemented to allow straightforward decision support across a variety of decision-making contexts in environmental health. The GUI allows users to easily import and recombine data, then analyze, visualize, highlight, export, and communicate ToxPi results. It also provides a statistical metric of stability for both individual ToxPi scores and relative prioritized ranks. Availability: The ToxPi GUI application, complete user manual, and example data files are freely available from http://comptox.unc.edu/toxpi.php.

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