EPA Science Inventory

Possible strategies for EDC testing in the future: exploring roles of pathway-based in silico, in vitro and in vivo methods

Citation:

Ankley, G. Possible strategies for EDC testing in the future: exploring roles of pathway-based in silico, in vitro and in vivo methods. Presented at Special Science Symposium for SETAC, October 23 - 25, 2012.

Description:

Current methods for screening, testing and monitoring endocrine-disrupting chemicals (EDCs) rely relatively substantially upon moderate- to long-term assays that can, in some instances, require significant numbers of animals. Recent developments in the areas of in vitro testing (e.g., high through-put technologies), in vitro/in vivo genomics, and computational biology (including bioinformatics) could provide the basis for efficiently detecting chemicals with the potential to perturb specific biological pathways within the hypothalamic-pituitary-gonadal and -thyroidal axes. These approaches, while not yet capable of wholly replacing longer-term whole-organism tests, nonetheless could fill roles related to screening/prioritization of large numbers of test chemicals for endocrine activities, or rapid broad-scale environmental monitoring of EDCs. This presentation will explore some of the newer technologies being considered for EDC testing and monitoring, including their potential advantages and drawbacks.

Purpose/Objective:

not applicable

URLs/Downloads:

ABSTRACT.PDF   (PDF,NA pp, 49 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (PRESENTATION/SLIDE)
Start Date: 10/23/2012
Completion Date: 10/23/2012
Record Last Revised: 12/20/2012
Record Created: 10/31/2012
Record Released: 10/31/2012
OMB Category: Other
Record ID: 247272

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

MID-CONTINENT ECOLOGY DIVISION