EPA Science Inventory

ExpoCast: High Throughput Exposure Prediction

Citation:

WAMBAUGH, J. F. ExpoCast: High Throughput Exposure Prediction. Presented at USDA FSIS; Organized by NERL HEASD (via Teleconference), Washington, DC, August 14, 2012.

Description:

See attached power point presentation in pdf

Purpose/Objective:

There are thousands of chemicals, many without enough data for evaluation – working to provide a high-throughput exposure approach to use with the ToxCast chemical hazard identification. TSCA21: Prioritization of ~500 Toxic Substances Control Act (TSCA) chemicals; EDSP21: Prioritization of ~2000 Endocrine Disruptors Screening Program (EDSP) chemicals; OW21: Development of next chemical contaminants list (CCL); Using fate and transport models to predict the contribution from manufacture and industrial use to overall exposure rapidly and efficiently; Applying and developing new high throughput models of consumer use and indoor exposure. ExpoCast can use environmental fate and transport models to make high- throughput exposure predictions. These prioritizations have been ground-truthed with CDC NHANES data; This biomonitoring data gives empirical calibration and estimate of uncertainty; Indoor/consumer use is a primary determinant; Next steps: HT models for exposure from consumer use and indoor environment; Use and evaluate these models as additional HT exposure assays

URLs/Downloads:

ExpoCast: High Throughput Exposure Prediction   (PDF,NA pp, 757 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (PRESENTATION/SLIDE)
Start Date: 08/14/2012
Completion Date: 08/14/2012
Record Last Revised: 10/25/2012
Record Created: 10/15/2012
Record Released: 10/15/2012
OMB Category: Other
Record ID: 246893

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR COMPUTATIONAL TOXICOLOGY

IMMEDIATE OFFICE