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Species-Specific Predictive Signatures of Developmental Toxicity using the ToxCast Chemical Library ( DART 2nd Species Workgroup)
Citation:
SIPES, N. Species-Specific Predictive Signatures of Developmental Toxicity using the ToxCast Chemical Library ( DART 2nd Species Workgroup). Presented at ILSI-HESI DART Technical Committee, 2nd Species Meeting; ILSI HESI Offices, 1156, 15th St., NW, 2nd Floor West Conference Room, Washington, DC, September 25, 2012.
Impact/Purpose:
Species predictive models of developmental toxicity give >70% BA Species-specific assay targets may be contributing to differential pathways of developmental toxicity It is feasible to use predictive models in conjunction with animal data Prioritize chemicals for testing in one species Rat in vivo followed by rabbit predictive model Early findings indicate we can bring additional assays into predictive models for a broader range of developmental toxicants in Phase II
Description:
See attached power point presentation for description.