EPA Science Inventory

Species-Specific Predictive Signatures of Developmental Toxicity using the ToxCast Chemical Library ( DART 2nd Species Workgroup)

Citation:

SIPES, N. Species-Specific Predictive Signatures of Developmental Toxicity using the ToxCast Chemical Library ( DART 2nd Species Workgroup). Presented at ILSI-HESI DART Technical Committee, 2nd Species Meeting; ILSI HESI Offices, 1156, 15th St., NW, 2nd Floor West Conference Room, Washington, DC, September 25, 2012.

Description:

See attached power point presentation for description.

Purpose/Objective:

Species predictive models of developmental toxicity give >70% BA Species-specific assay targets may be contributing to differential pathways of developmental toxicity It is feasible to use predictive models in conjunction with animal data Prioritize chemicals for testing in one species Rat in vivo followed by rabbit predictive model Early findings indicate we can bring additional assays into predictive models for a broader range of developmental toxicants in Phase II

URLs/Downloads:

Species-Specific Predictive Signatures of Developmental Toxicity using the ToxCast Chemical Library   (PDF,NA pp, 1788 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (PRESENTATION/SLIDE)
Start Date: 09/25/2012
Completion Date: 09/25/2012
Record Last Revised: 10/31/2012
Record Created: 10/10/2012
Record Released: 10/10/2012
OMB Category: Other
Record ID: 246834

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR COMPUTATIONAL TOXICOLOGY

IMMEDIATE OFFICE