EPA Science Inventory

Risk of lung cancer associated with six types of chlorinated solvents: results from two case-control studies in Montreal, Canada

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Citation:

Vizcaya, D., K. L. CHRISTENSEN, J. Lavoue, AND J. Siemiatycki. Risk of lung cancer associated with six types of chlorinated solvents: results from two case-control studies in Montreal, Canada. OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. BMJ / British Medical Journal Publishing Group, London, Uk, 70(2):81-85, (2012).

Description:

Methods: Two case-control studies of occupation and lung cancer were conducted in Montreal, including 2,016 cases and 2,001 population controls. Occupational exposure to a host of agents was evaluated using a combination of subject-reported job history and expert assessment. We examined associations between lung cancer among men and six specific chlorinated solvents and two chemical families (chlorinated alkanes and alkenes). Odds ratios were calculated using unconditional multivariate logistic analysis. Results: Pooling the two studies, there was an increased risk of lung cancer associated with occupational exposure to carbon tetrachloride (OR=2.5, 95% CI: 1.1-5.7) and perchloroethylene (OR=2.4, 95% CI: 0.8-7.7). There were no other chlorinated solvents that exhibited both statistically significant associations and indications of dose-response. Risk estimations appeared to be higher among non-smokers. Subgroup analyses indicated possible differences by histologic subtype. Conclusions: Exposure to perchloroethylene and carbon tetrachloride may increase the risk of lung cancer. Results for other solvents were equivocal.

Purpose/Objective:

To determine whether exposure to various chlorinated solvents is associated with lung cancer.

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 09/19/2013
Completion Date: 09/19/2013
Record Last Revised: 03/11/2014
Record Created: 09/27/2012
Record Released: 09/27/2012
OMB Category: Other
Record ID: 246562

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT

WASHINGTON DC

QUANTITATIVE AND RISK METHODS GROUP