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Soluble Ions with ICP-MS are Superior to Total Elements with XRF in Assessing Component-specific Cardiovascular Effects of Fine Particulate Matter
Citation:
Neas, L., A. Schneider, K. Kovalcik, M. Herbst, A. Hinderliter, M. Case, R. Williams, W. Cascio, A. Peters, AND R. Devlin. Soluble Ions with ICP-MS are Superior to Total Elements with XRF in Assessing Component-specific Cardiovascular Effects of Fine Particulate Matter. Presented at International Society for Environmental Epidemiology, August 26 - 30, 2012.
Impact/Purpose:
to be submitted to a conference
Description:
Background: We previously reported that total fine particulate matter (PM2.5) was associated with flow-mediated dilation (FMD), interleukin-6 (lL-6) and tumor-necrosisfactor-alpha (TNFa) in 22 individuals with type 2 diabetes. Objectives: We now compare two laboratory methods of assessing PM2.5 constituents. Methods: We conducted a prospective panel study with four repeated measurements. Total elemental composition was analyzed by x-ray florescence (XRF). Water-soluble extractions were analyzed using inductively coupled plasma mass spectrometry (lCPMS). Results from models with random patient effects are presented as %-changes [95%confidence intervals] for a method-specific interquartile change. Results: Moderate Pearson correlations between ICP-MS and XRF measurements were seen for copper (0.55), zinc (0.67), iron (0.61), and selenium (0.70). The association of copper and FMD (lagO) was much stronger with ICP-MS (-16.2% [-26.9 to -5.6] per 16.4ug/L) than with XRF (-12.7% [-27.6 to +2.2] per 1.9ng/m3). The association of selenium and FMD (lagO) was identical, but more precise, with ICP-MS (-11.9% [-22.3 to -1.6] per 19.7ug/L) than with XRF (-12.0% [-26.7 to +2.7] per 1.4ng/m3). The association of zinc and IL-6 (lag2) was stronger with ICP-MS (+21.3% [8.6 to 34.0] per 146.9ug/L) than with XRF (+10.9% [-3.7 to +25.6] per 6.6ng/m3). The association of iron and TNFa (lag2) was stronger with ICP-MS (+12.2% [6.1 to 18.2] per 275.8ug/L) than with XRF (+8.2% [3.3 to 13.2] per 44.1ng/m3). Conclusions: Water-soluble components measured with ICP-MS are superior to total elements measured with XRF in assessing component-specific cardiovascular effects.