EPA Science Inventory

A short-term study investigating the estrogenic potency of diethylstilbesterol in the fathead minnow (Pimephales promelas)

Citation:

Adedeji, O., E. Durhan, M. Kahl, K. Jensen, C. LaLone, L. Makynen, L. Thomas, D. Villeneuve, AND G. Ankley. A short-term study investigating the estrogenic potency of diethylstilbesterol in the fathead minnow (Pimephales promelas). ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 46(14):7826-7835, (2012).

Description:

Diethylstilbestrol (DES) is a synthetic estrogen that has been banned for use in humans, but still is employed in livestock and aquaculture operations in some parts of the world. Detectable concentrations of DES in effluent and surface waters have been reported to range from slightly below 1 to greater than 10 ng/L. Little is known, however, concerning the toxicological potency of DES in fish. Overall, our studies show that DES causes a range of estrogenic responses in fish at water concentrations comparable to those reported in the environment, and that in vivo potency of the estrogen is on par with that of the better-studied estrogenic contaminant 17alpha-ethinylestradiol.

Purpose/Objective:

Overall, our studies show that DES causes a range of estrogenic responses in fish at water concentrations comparable to those reported in the environment, and that in vivo potency of the estrogen is on par with that of the better-studied estrogenic contaminant 17alpha-ethinylestradiol.

URLs/Downloads:

epa.gov

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 07/17/2012
Completion Date: 07/17/2012
Record Last Revised: 01/24/2013
Record Created: 08/08/2012
Record Released: 08/08/2012
OMB Category: Other
Record ID: 245433

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

MID-CONTINENT ECOLOGY DIVISION