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In vivo testing of chemicals that undergo substantial biotransformation: An opportunity to advance in vitro-in vivo metabolism extrapolation procedures for fish
Citation:
Nichols, J. In vivo testing of chemicals that undergo substantial biotransformation: An opportunity to advance in vitro-in vivo metabolism extrapolation procedures for fish. Presented at Health and Environmental Sciences/HESI Workshop on In Vivo Bioaccumulation Testing with Fish.
Impact/Purpose:
This is one of several keynote presentations given at the beginning of a one-day workshop on in vivo testing with fish. The purpose of this talk is to describe recent progress on using in vitro data to predict metabolism impacts on chemical accumulation by fish. The focus of this workshop is on development and application of new methods for measuring chemical accumulation. The primary conclusion of my talk is that researchers working on these methods should partner with other scientists who are working on in vitro-in vivo metabolism extrapolation procedures as a means of validating these methods.
Description:
This is one of several keynote presentations given at the beginning of a one-day workshop on in vivo testing with fish. The purpose of this talk is to describe recent progress on using in vitro data to predict metabolism impacts on chemical accumulation by fish. The focus of this workshop is on development and application of new methods for measuring chemical accumulation. The primary conclusion of my talk is that researchers working on these methods should partner with other scientists who are working on in vitro-in vivo metabolism extrapolation procedures as a means of validating these methods.