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Predicting the accumulation of well-metabolized chemicals by fish from measured rates of in vitro intrinsic clearance: Progress made and challenges ahead
Citation:
Nichols, J., A. Hoffman, P. Fitzsimmons, K. Fay, AND T. Ter Laak. Predicting the accumulation of well-metabolized chemicals by fish from measured rates of in vitro intrinsic clearance: Progress made and challenges ahead. Presented at Invited oral presentation, Stockholm University.
Impact/Purpose:
Several groups have extrapolated in vitro metabolism data for fish to the intact animal and used this information as an input to models of chemical bioconcentration. These “proof of concept” studies show that incorporating in vitro metabolism data into the models substantially “improves” predicted BCF values (compared to predictions without metabolism) by moving them in the direction of measured values. Despite this progress, however, substantial uncertainties remain concerning critical modeling inputs and assumptions. The purpose of this talk is to describe ongoing and planned studies being conducted in our laboratory which address these inputs and assumptions.
Description:
Several groups have extrapolated in vitro metabolism data for fish to the intact animal and used this information as an input to models of chemical bioconcentration. These “proof of concept” studies show that incorporating in vitro metabolism data into the models substantially “improves” predicted BCF values (compared to predictions without metabolism) by moving them in the direction of measured values. Despite this progress, however, substantial uncertainties remain concerning critical modeling inputs and assumptions. The purpose of this talk is to describe ongoing and planned studies being conducted in our laboratory which address these inputs and assumptions.