You are here:
Stereo- and regio-selective one-pot synthesis of triazole-based unnatural amino acids and β- amino triazoles
Citation:
Baig, N. AND R. Varma. Stereo- and regio-selective one-pot synthesis of triazole-based unnatural amino acids and β- amino triazoles. CHEMICAL COMMUNICATIONS. RSC Publishing, Cambridge, Uk, 48(47):5853 - 5855, (2012).
Impact/Purpose:
Describe a green protocol that is applicable to a broad substrate scope and has significant potential for the synthesis of unnatural amino acids with triazole side chain.
Description:
Synthesis of triazole based unnatural amino acids and β-amino triazole has been described via stereo and regioselective one-pot multi-component reaction of sulfamidates, sodium azide, and alkynes under MW conditions. The developed method is applicable to a broad substrate scope and has significant potential for the synthesis of unnatural amino acids with triazole side chain.
