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Response to “Accurate Risk-Based Chemical Screening Relies on Robust Exposure Estimates”
Citation:
WETMORE, B. A., J. F. WAMBAUGH, S. S. FERGUSON, M. A. SOCHASKI, D. ROTROFF, K. FREEMAN, H. J. CLEWELL III, D. J. DIX, M. E. ANDERSEN, K. A. HOUCK, B. ALLEN, R. JUDSON, R. SINGH, R. J. KAVLOCK, A. M. RICHARD, AND R. S. THOMAS. Response to “Accurate Risk-Based Chemical Screening Relies on Robust Exposure Estimates”. TOXICOLOGICAL SCIENCES. Oxford University Press, Cary, NC, 128(1):297-299, (2012).
Impact/Purpose:
We agree that both robust exposure and dosimetry estimates are needed for accurate risk-based chemical screening. Although there are some limitations in our study, they were explicitly noted in the paper. Further research will reveal the relative impact of the assumptions with the present approach. Importantly, we believe the effort represents an essential first step in using high-throughput in vitro screening for prioritization and decision making and that further refinements of the approach will enhance its utility.
Description:
This is a correspondence (letter to the editor) with reference to comments by Rudel and Perovich on the article "Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment". Article Reference: SI # 238882
