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Opportunities for animal alternatives implementation in the evolving OECD fish testing framework
Citation:
Belanger, S., G. Ankley, P. Matthiessen, G. Maack, T. Iguchi, K. Willet, M. Embry, J. Wheeler, AND A. Gourmelon. Opportunities for animal alternatives implementation in the evolving OECD fish testing framework. To be Presented at SETAC Europe.
Impact/Purpose:
Not applicable
Description:
This presentation reviews opportunities for animal alternative approaches in the FTF. These will be placed in the context of in vivo tests required in many regulatory situations for the registration of industrial chemicals, pharmaceuticals, and agrochemicals. The Framework integrates current thinking regarding screening assessments, acute toxicity, chronic toxicity, bioaccumulation, and endocrine disruption determinations. Ample room exists for improved use of in vitro, embryo tests, threshold approaches, and implementation of robust experimental designs. The overall goal is to minimize animal use while maximizing the collection of information useful in hazard and risk assessment, and classification and labelling. Method development needs and future opportunities will be identified throughout.