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Comptational comparison of asbestos fibers: Dosimetry model simulations to characterize variabilty and potency (Presentation poster)
Citation:
JARABEK, A. M., O. T. Price, S. H. GAVETT, AND B. Asgharian. Comptational comparison of asbestos fibers: Dosimetry model simulations to characterize variabilty and potency (Presentation poster). To be Presented at Society of Toxicology Annual Meeting, San Francisco, CA, March 11 - 15, 2012.
Impact/Purpose:
Presentation poster
Description:
Inhaled asbestos fibers result in respiratory diseases such as asbestosis, lung cancer and mesothelioma, but different asbestos fibers exhibit different potency. We applied a recently developed dosimetry model (Asgharian et al., Poster # 104) that describes the aerodynamic behavior of inhaled fibers and resultant deposition fractions (DF) in the human and rat respiratory tracts to compare DF between environmental exposures of Libby amphibole (LA) and amosite (AM). Physiological parameters such as airway architecture, minute ventilation rate (VE) and breathing mode (nasal or oral) can be varied in such models to explore uncertainty inherent in risk assessments using average exposure or default intake values. We explore the impact of ventilation rate, age, and species differences on various internal dose metrics to gain insights on potential differences in potency for LA and AM.