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Appendix E. Analysis of Chronic Toxicity Data and Acute Chronic Ratios (ACRs) in Support of Deriving Chronic HC5s: Acetylcholinesterase Inhibitors
Citation:
MOUNT, D. R. Appendix E. Analysis of Chronic Toxicity Data and Acute Chronic Ratios (ACRs) in Support of Deriving Chronic HC5s: Acetylcholinesterase Inhibitors. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-13/003, 2011.
Impact/Purpose:
The analysis described in this appendix is one of several conducted in support of developing a common methodology for assessing chemical effects on aquatic animals for use by the USEPA Office of Pesticide Programs (OPP) and the Office of Water (OW). Other appendices describe methods for estimating/predicting the acute toxicity values and/or the acute HC5, the 5th percentile in a species sensitivity distribution for acute toxicity. However, effects assessments by both OPP and OW also require estimation of chronic toxicity thresholds. This could include predicting chronic thresholds for specific organisms, or the estimation of the chronic HC5, the 5th percentile of a chronic species sensitivity distribution.
Description:
The analysis described in this appendix is one of several conducted in support of developing a common methodology for assessing chemical effects on aquatic animals for use by the USEPA Office of Pesticide Programs (OPP) and the Office of Water (OW). Other appendices describe methods for estimating/predicting the acute toxicity values and/or the acute HC5, the 5th percentile in a species sensitivity distribution for acute toxicity. However, effects assessments by both OPP and OW also require estimation of chronic toxicity thresholds. This could include predicting chronic thresholds for specific organisms, or the estimation of the chronic HC5, the 5th percentile of a chronic species sensitivity distribution.