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Determination of Perfluorinated Alkyl Acid Concentrations in Biological Standard Reference Materials
Citation:
Reiner, J. L., S. G. O'Connell, C. M. Butt, S. A. Mabury, J. M. Small, A. O. De Silva, D. G. Muir, A. DELINSKY, M. STRYNAR, A. B. LINDSTROM, W. K. Reagen, M. Malinsky, S. Schafer, C. A. Kwadijk, M. M. Schantz, AND J. M. Keller. Determination of Perfluorinated Alkyl Acid Concentrations in Biological Standard Reference Materials. Analytical Bioanalytical Chemistry . Springer-Verlag, Berlin, Germany, 404(9):2683-2692, (2012).
Impact/Purpose:
The National Exposure Research Laboratory′s (NERL) Human Exposure and Atmospheric Sciences Division (HEASD) conducts research in support of EPA′s mission to protect human health and the environment. HEASD′s research program supports Goal 1 (Clean Air) and Goal 4 (Healthy People) of EPA′s strategic plan. More specifically, our division conducts research to characterize the movement of pollutants from the source to contact with humans. Our multidisciplinary research program produces Methods, Measurements, and Models to identify relationships between and characterize processes that link source emissions, environmental concentrations, human exposures, and target-tissue dose. The impact of these tools is improved regulatory programs and policies for EPA.
Description:
Standard reference materials (SRMs) are homogeneous, well-characterized materials used to validate measurements and improve the quality of analytical data. The National Institute of Standards and Technology (NIST) has a wide range of SRMs that have mass fraction values assigned for legacy pollutants. These SRMs can also serve as test materials for method development, method validation, and measurement for contaminants of emerging concern. Because inter-laboratory comparison studies have revealed substantial variability of measurements of perfluoroalkyl acids (PFAAs), future analytical measurements will benefit from determination of consensus values for PFAAs in SRMs to provide a means to demonstrate method-specific performance. To that end, NIST, in collaboration with other groups, has been measuring concentrations of PFAAs in a variety of SRMs. Here we report levels of PFAAs and perfluorooctane sulfonamide (PFOSA) determined in four biological SRMs: fish tissue (SRM 1946 Lake Superior Fish Tissue, SRM 1947 Lake Michigan Fish Tissue), bovine liver (SRM 1577c), and mussel tissue (SRM 2974a). We also report concentrations for three in-house quality-control materials: beluga whale liver, pygmy sperm whale liver, and white-sided dolphin liver. Measurements in SRMs show an array of PFAAs, with perfluorooctane sulfonate (PFOS)
URLs/Downloads:
Analytical and Bioanalytical Chemistry
Determination of Perfluorinated Alkyl Acid Concentrations in Biological Standard Reference Materials (PDF, NA pp, 4946 KB, about PDF)