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Using Microelectrode Arrays for Neurotoxicity Screening
Citation:
SHAFER, T. J. Using Microelectrode Arrays for Neurotoxicity Screening. Presented at Institute for Scientific Communications 10th International Conference on Early Toxicity Screening, Seattle, WA, June 14 - 15, 2012.
Impact/Purpose:
Microelectrode arrays (MEAs) allow the assessment ofelectrical activity in primary cultures and slices ofnervous system tissues, and detect the effects ofmany compound classes
Description:
Chemicals can disrupt nervous system electrical activity, rapidly causing toxicity prior to, or in the absence of, biochemical or morphological changes. However, high-throughput, functional approaches to detect chemical induced changes in electrical excitability are lacking. Microelectrode arrays (MEAs) allow the assessment ofelectrical activity in primary cultures and slices ofnervous system tissues, and detect the effects ofmany compound classes. Examples of using MEAs to determine relative potency, screen and classify sets of chemicals for neuroactivity and assay compounds for the potential to cause developmental neurotoxicity will be presented. (This abstract does not represent Agency policy).