EPA Science Inventory

MetaPath: An Electronic Knowledge Base for Collating, Exchanging and Analyzing Case Studies of Xenobiotic Metabolism

Citation:

KOLANCZYK, R. C., P. SCHMIEDER, W. J. JONES, O. G. MEKENYAN, A. CHAPKANOV, S. TEMELKOV, S. KOTOV, M. VELIKOVA, V. KAMENSKA, K. VASILEV, AND G. D. VEITH. MetaPath: An Electronic Knowledge Base for Collating, Exchanging and Analyzing Case Studies of Xenobiotic Metabolism. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 63(1):84-96, (2012).

Description:

A new MetaPath information system was developed through a collaborative effort between the Laboratory of Mathematical Chemistry (Bourgas, Bulgaria), EPA’s Office of Research and Development (NHEERL, MED, Duluth, MN and NERL, ERD, Athens, GA), and EPA’s Office of Chemical Safety and Pollution Prevention (OPP, Arlington VA). Metabolism data plays a critical role in the risk assessment process. Regulatoryauthorities must manage, document and review large amounts of data on metabolism for pesticide chemicals. The MetaPath system serves to store summary information on pesticide metabolism and environmental degradates that is obtained from the expert reviews of submitted regulatory studies in a structure searchable manner that will increase efficiency of information retrieval in the pesticide program, and allow critical analysis and interpretation of data in a manner currently not possible.

Purpose/Objective:

To document research results.

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 06/01/2012
Completion Date: 06/01/2012
Record Last Revised: 10/10/2012
Record Created: 12/19/2011
Record Released: 12/19/2011
OMB Category: Other
Record ID: 240130

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

MID-CONTINENT ECOLOGY DIVISION

MOLECULAR & CELLULAR MECHANISMS RESEARCH