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Proteomic analysis of a model fish species exposed to individual pesticides and a binary mixture
Citation:
BIALES, A. D., D. C. BENCIC, R. W. FLICK, K. A. BLOCKSOM, J. M. LAZORCHAK, AND D. L. LATTIER. Proteomic analysis of a model fish species exposed to individual pesticides and a binary mixture . AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 101(1):196-206, (2011).
Impact/Purpose:
The identification of differentially expressed proteins may prove to be useful in understanding the mode of action of binary mixtures. Moreover, the permethrin PES may be helpful in ecological risk assessment by reducing the complexity of mixture exposures.
Description:
Aquatic organisms are often exposed to multiple pesticides simultaneously. Due to the relatively poor characterization of mixture constituent interactions and the potential for highly complex exposure scenarios, there is considerable uncertainty in understanding the toxicity of mixture exposures. Expression based biomarkers may be useful in reducing the complexity in mixtures by identifying the biologically active constituents. Here we characterize the proteomic responses of male fathead minnows in single exposures to the pesticides permethrin and terbufos and a binary mixture of both.
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Proteomic analysis of a model fish species exposed to individual pesticides and a binary mixture