EPA Science Inventory

Effects of Air Pollutants on Innate Immunity: The Role of Toll-like receptors and nucleotide-binding oligomerization domain-like receptors

Citation:

Bauer, R. N., D. DIAZ SANCHEZ, AND I. JASPERS. Effects of Air Pollutants on Innate Immunity: The Role of Toll-like receptors and nucleotide-binding oligomerization domain-like receptors. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. Journal of Allergy Clinical Immunology, 129(1):14-24, (2012).

Description:

Interactions between exposure to ambient air pollutants and respiratory pathogens have been shown to modify respiratory immune responses. Emerging data suggest key roles for toll-like receptor (TLR) and NOD-like receptor (NLR) signaling in pathogen-induced immune responses. Similarly, immune responses elicited by exposure to air pollutants are mediated by specific TLR and NLR-dependent mechanisms. This review article will summarize current knowledge about how air pollutants modify TLR and NLR dependent signaling and host defense responses in the lung.

Purpose/Objective:

This review article will summarize current knowledge about how air pollutants modify TLR and NLR dependent signaling and host defense responses in the lung.

URLs/Downloads:

JOURNAL OF ALLERGY CLINICAL IMMUNOLOGY   Exit

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 01/01/2012
Completion Date: 01/01/2012
Record Last Revised: 10/22/2012
Record Created: 09/14/2011
Record Released: 09/14/2011
OMB Category: Other
Record ID: 238236

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

ENVIRONMENTAL PUBLIC HEALTH DIVISION

CLINICAL RESEARCH BRANCH