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The Utility of Naphthyl-Keratin Adducts as Biomarkers for Jet-Fuel Exposure
Citation:
Kang-Sickel, J. C., M. A. Butler, L. Frame, B. Serdar, Y. E. Chao, P. P. EGEGHY, S. M. Rappaport, C. A. Toennis, W. Li, T. Borisova, J. E. French, AND L. A. Nylander-French. The Utility of Naphthyl-Keratin Adducts as Biomarkers for Jet-Fuel Exposure. BIOMARKERS. Taylor & Francis, Inc., Philadelphia, PA, 16(7):590-2599, (2011).
Impact/Purpose:
The National Exposure Research Laboratory′s (NERL) Human Exposure and Atmospheric Sciences Division (HEASD) conducts research in support of EPA′s mission to protect human health and the environment. HEASD′s research program supports Goal 1 (Clean Air) and Goal 4 (Healthy People) of EPA′s strategic plan. More specifically, our division conducts research to characterize the movement of pollutants from the source to contact with humans. Our multidisciplinary research program produces Methods, Measurements, and Models to identify relationships between and characterize processes that link source emissions, environmental concentrations, human exposures, and target-tissue dose. The impact of these tools is improved regulatory programs and policies for EPA.
Description:
We investigated the association between biomarkers of dermal exposure, naphthyl-keratin adducts (NKA), and urine naphthalene biomarker levels in 105 workers routinely exposed to jet-fuel. A moderate correlation was observed between NKA and urine naphthalene levels (p = 0.061). The NKA, post-exposure breath naphthalene, and male gender were associated with an increase, while CYP2E1*6 DD and GSTT1-plus (++/+-) genotypes were associated with a decrease in urine naphthalene level (p < 0.0001). The NKA show great promise as biomarkers for dermal exposure to naphthalene. Further studies are warranted to characterize the relationship between NKA, other exposure biomarkers, and/or biomarkers of biological effects due to naphthalene and/or PAH exposure.
URLs/Downloads:
Biomarkers
The Utility of Naphthyl-Keratin Adducts as Biomarkers for Jet-Fuel Exposure (PDF, NA pp, 138 KB, about PDF)