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IRIS Toxicological Review of Chloroprene (Final Report)
Citation:
U.S. EPA. IRIS Toxicological Review of Chloroprene (Final Report). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/010F, 2010.
Impact/Purpose:
Chloroprene (CASRN 126-99-8) or 2-chloro-1,3-butadiene is a volatile liquid monomer used exclusively in the manufacture of polychloroprene (neoprene) elastomer.
Description:
The final Toxicological Review of Chloroprene provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to chloroprene. Chloroprene (C4H5Cl) is a volatile, flammable liquid used primarily in the manufacture of polychloroprene or neoprene rubber. The latter is used to make diverse products, such as tires, wire coatings, and tubing. Human health risk concerns for chloroprene are primarily related to exposures via effluent and emissions from facilities that use chloroprene to produce polychloroprene elastomers or transport the product, although these exposure concerns have not been well characterized.
This assessment contains the derivation of a chronic inhalation reference concentration (RfC) and chronic cancer inhalation unit risk.
URLs/Downloads:
IRIS Toxicological Review of Chloroprene (PDF, 303 pp, 3162 KB, about PDF)IRIS Summary for Chloroprene (PDF, 30 pp, 266 KB, about PDF)