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Behavioral changes in young and adult rats: Indications of cholinesterase inhibition
Citation:
MOSER, V. C., P. PHILLIPS, K. MCDANIEL, AND D. W. HERR. Behavioral changes in young and adult rats: Indications of cholinesterase inhibition. Presented at 2011 American Chemical Society Fall National Meeting, Denver, CO, August 28 - September 01, 2011.
Impact/Purpose:
Overall we have shown that there are several patterns of behavior:enzyme correlations that are chemical-specific. Furthermore, these correlations are distinctly different between adult and young animals.
Description:
Inhibition of acetylcholinesterase (AChE) has long been accepted as the basis for neurotoxicity produced by organophosphorus (OP) and N-methyl carbamate chemicals. Functional or behavioral alterations result from acute exposure to these chemicals. We have conducted behavioral evaluations and concurrent AChE inhibition measures for many OPs and carbamates in both adult and preweanling rats. In many cases a within-subject design allows direct correlations, and in one case tissue levels are also available to complete the linkages from dosimetry to effect. Overall we have shown that there are several patterns of behavior:enzyme correlations that are chemical-specific. Furthermore, these correlations are distinctly different between adult and young animals. These data can be modeled to inform PBPK/PD predictions of OP and carbamate neurotoxicity. This is an abstract of a proposed presentation and does not reflect US EPA policy.