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ASSOCIATION OF URINARY PERCHLORATE WITH INDIRECT MEASURES OFTHYROID DYSFUNCTION BASED ON NHANES 2001-2002
Citation:
SCHREINEMACHERS, D. M. ASSOCIATION OF URINARY PERCHLORATE WITH INDIRECT MEASURES OFTHYROID DYSFUNCTION BASED ON NHANES 2001-2002. Presented at International Society for Environmental Epidemiology (ISEE) 2011 Conference, Barcelona, SPAIN, September 13 - 16, 2011.
Impact/Purpose:
This study is based on NHANES 2001-2002, and investigates associations between urinary perchlorate and indirect markers of subclinical hypothyroidism, such as decreased high density lipoprotein (HDL) and several hematologic measures, e.g. ferritin, serum iron, percent transferrin saturation, hemoglobin, and hematocrit.
Description:
Background/Aims: Perchlorate is a widespread environmental pollutant. Previous population studies based on the National Health and Nutrition Examination Survey (NHANES) 2001-2002, showed that urinary perchlorate concentrations were associated with increased levels of thyroid stimulating hormone for women, and decreased levels of total thyroxine for women with low urinary iodine. The study presented here shows that in addition to direct effects on measures of thyroid function among women, indirect measures of thyroid dysfunction can also be observed among both men and women. Methods: This study is based on NHANES 2001-2002, and investigates associations between urinary perchlorate and indirect markers of subclinical hypothyroidism, such as decreased high density lipoprotein (HDL) and several hematologic measures, e.g. ferritin, serum iron, percent transferrin saturation, hemoglobin, and hematocrit. Regression analyses were conducted for males, ages 6-19 and 20-85; girls, ages 6-14; non-pregnant women of reproductive age (15-49); pregnant women; and women ages 50-85. Associations with both linear and nonlinear measures of perchlorate were investigated. Results: Although the levels of the effect biomarkers were all within reference ranges, significant associations with urinary perchlorate were observed. For example, with increasing urinary perchlorate, serum iron and percent transferrin saturation were significantly decreased among all subject groups. Hemoglobin and hematocrit were decreased among males age 6-19, pregnant women, and nonpregnant women of reproductive age. HDLwas decreased among men, age 20-85. Conclusion: This is the first study to demonstrate an association between environmental perchlorate exposure and indirect markers of subclinical hypothyroidism, such as decreased levels of HDLand hematologic markers. Disclaimer: This is an abstract of a proposed presentation and does not reflect EPApolicy.