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IRIS Toxicological Review of Methanol (Non-Cancer) (External Review Draft; April 2011)
EPA announces the release of the Toxicological Review of Methanol (Non-Cancer) in the Apr 18, 2011 Federal Register Notice. This draft assessment is provided for public viewing and comment. Public comments received on the Toxicological Review within 60 days after the release of the FRN will be provided to the external peer reviewers for their consideration. Any comments not received within the requested time period will be considered by EPA in their revisions. [Update] EPA is releasing an addendum to the draft report and announcing a 14-day public comment period for review of the addendum. The purpose of this addendum is to provide the public with several recent studies that were published between the initial release of the methanol assessment in January 2010 and the recent re-release of the non-cancer portion of that assessment in April 2011. Due to the unusual step of placing the methanol assessment on hold (as described in the April 18, 2011 Federal Register Notice), and the length of time that elapsed since the initial release of the assessment, EPA decided to issue the addendum addressing these additional studies. Description and analyses of these studies are included in the addendum. Note: A revised charge to external peer reviewers was posted on Jul 1, 2011 to correct a typographical error in the background section.
Citation:
U.S. EPA. IRIS Toxicological Review of Methanol (Non-Cancer) (External Review Draft; April 2011). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/001A, 2011.
Impact/Purpose:
EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of methanol (non-cancer) that will appear in the Integrated Risk Information System (IRIS) database.
Description:
EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of methanol (non-cancer) that when finalized will appear on the Integrated Risk Information System (IRIS) database.
URLs/Downloads:
IRIS Toxicological Review of Methanol (Non-Cancer) (External Review Draft) (PDF, 382 pp, 9876 KB, about PDF)Charge to External Peer Reviewers (PDF, 4 pp, 26 KB, about PDF)
Consolidated Comments from the External Peer Review (Final) (PDF, 134 pp, 635 KB, about PDF)
Addendum to Methanol (non-cancer) Tox Review (Added 6/22/11) (PDF, 11 pp, 243 KB, about PDF)
PBPK code and supporting files for implementation in acslX (AEgis Technologies)
NEDO: Toxicological Research of Methanol as a Fuel for Power Station (Oct 1987) Scanned PDF (PDF, 289 pp, 12000 KB, about PDF)
Comments from Peer Reviewers on the NEDO Methanol Review (Jun 2009) (PDF, 109 pp, 436 KB, about PDF)
1. Table of Average Values(1) (PDF, 265 pp, 10000 KB, about PDF)
2. Table of Average Values(2) (PDF, 375 pp, 12000 KB, about PDF)
3. Individual Density & Individual Body Weight (PDF, 374 pp, 25000 KB, about PDF)
4. Individual Body Weight Gain (PDF, 370 pp, 26000 KB, about PDF)
5. Individual Food Consumption Rate, Individual Laboratory Test Results, Individual Organ Weight, Individual Body Weight to Organ Weight Ratio (PDF, 268 pp, 17000 KB, about PDF)
6. Individual Major Pathological Findings & Pathological Findings (Male) (PDF, 352 pp, 17000 KB, about PDF)
7. Individual Major Pathological Findings & Pathological Findings (Female) (PDF, 339 pp, 16000 KB, about PDF)
8. Histopathological Sample Photographs (PDF, 33 pp, 3000 KB, about PDF)
9. Supporting Documents (PDF, 53 pp, 708 KB, about PDF)
18-Month Carcinogenicity Inhalation Toxicity of Methanol in Mice: Main Discussion & Support Documents (PDF, 119 pp, 3000 KB, about PDF)
1. Table of Average Values (PDF, 475 pp, 16000 KB, about PDF)
2. Individual Density & Individual Body Weight (PDF, 358 pp, 20000 KB, about PDF)
3. Individual Body Weight Gain (PDF, 342 pp, 18000 KB, about PDF)
4. Individual Food Consumption Rate, Individual Urinalysis, Individual Hematological Tests, Individual Hemograms, Individual Plasma Biochemical Tests, Individual Organ Weight, Individual Organ Weight (PDF, 215 pp, 11000 KB, about PDF)
5. Individual Major Pathological Findings & Pathological Findings (Male) (PDF, 445 pp, 19000 KB, about PDF)
6. Individual Major Pathological Findings & Pathological Findings (Female) (PDF, 468 pp, 20000 KB, about PDF)
7. Histopathological Sample Photographs (PDF, 28 pp, 2000 KB, about PDF)
24-Month Carcinogenicity Inhalation Toxicity Test of Methanol in Rats: Main Discussion & Supporting Documents (PDF, 80 pp, 2960 KB, about PDF)
FR Notice: Jun 22, 2011
FR Notice: Apr 18, 2011
REVISED
Peer Review Plan (PDF, NA pp, 33 KB, about PDF)