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Biomarkers of Oxidative Stress Study IV. Are Antioxidants Markers of Ozone Exposure?
Citation:
Kadiiska, M. B., G. E. HATCH, A. Nyska, D. P. Jones, K. Hensley, R. Stocker, M. M. George, D. H. Van Thiel, K. Stadler, J. Barrett, AND R. P. Mason. Biomarkers of Oxidative Stress Study IV. Are Antioxidants Markers of Ozone Exposure? AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. American Thoracic Society, New York, NY, 51(9):1636-1642, (2011).
Impact/Purpose:
Antioxidants measured in blood plasma are not sensitive biomarkers for oxidative damage induced by the ozone. The present study suggests that monitoring of plasma antioxidant substances i not a sensitive indicator of ozone induced oxidative stress in animal models ore humans.
Description:
To determine whether the oxidative effects of ozone would result in losses of antioxidants from plasma, and possibly bronchoalveolar lavage fluid (BALF). This research is part of a comprehensive, multilaboratory validation study searching for noninvasive biomarkers of oxidative stress