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Lung Function and Inflammatory responses in healthy young adults exposed to 0.06 ppm Ozone for 6.6 hours
Citation:
KIM, C. S., H. R. KEHRL, A. RAPPOLD, M. W. CASE, M. T. SCHMITT, R. B. DEVLIN, D. DIAZ SANCHEZ, N. Alexis, M. Hazucha, J. Lay, AND D. Peden. Lung Function and Inflammatory responses in healthy young adults exposed to 0.06 ppm Ozone for 6.6 hours. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. American Thoracic Society, New York, NY, 183(9):1215-21, (2011).
Impact/Purpose:
The study found a small but statistically significant decrement of spirometric lung function and an increase in airway inflammation assessed by nutrophil influx in young healthy adults after 6.6 hour exposure to 0.06 ppm ozone that is below the current ozone NAAQS.
Description:
Rationale: Exposure to ozone causes a decrease in spirometric lung function and an increase in airway inflammation in healthy young adults at concentrations as low as 0.08 ppm close to the the National Ambient Air Quality Standard for ground level ozone. Objectives: To test whether airway effects occur below the current ozone standard and if they are more pronounced in potentially susceptible individuals, such as those deficient in the antioxidant gene glutathione S-transferase MI. Methods: Pulmonary function and subjective symptoms were measured in 59 healthy young adults (19-35 years) immediately before and after exposure to 0.0 (clean air, CA) and 0.06 ppm ozone for 6.6 hours in a chamber while undergoing intermittent moderate exercise. The polymorphonuclear neutrophil (PMN) influx was measured in 24 subjects 16-18 hour post-exposure. Measurements and Main Results: Subjects experienced a significantly greater (p=0.008) change in FEVl (±standard error) immediately following exposure to 0.06ppm ozone compared to CA (-1.76±0.50% vs. -0.002±0.46%). The decrement in FVC was also greater (p=0.02) after ozone vs. CA (-2.32±0.41% vs. -1.13±0.34%). Similarly, %PMN was greater after ozone (54.0±4.6%) than CA (38.3±3.7%) exposure (p
