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NCCT ToxCast Program for Nanomaterial Prioritization: High-Throughput Screening, Consideration of Exposure, and Bioactivity Profiling/Modeling
Citation:
WANG, A., K. A. HOUCK, S. GANGWAL, E. A. COHEN-HUBAL, R. W. SETZER, S. J. PADILLA, D. REIF, S. FRADY, AND D. J. DIX. NCCT ToxCast Program for Nanomaterial Prioritization: High-Throughput Screening, Consideration of Exposure, and Bioactivity Profiling/Modeling. Presented at USEPA/ORD Nanotechnology Symposium, Arlington, VA, November 15 - 16, 2010.
Impact/Purpose:
So many nanomaterials (NMs), so little time. Current assessment of NM is case-by-case, and research on NM toxicity and exposure cannot keep up with the development of new materials and applications. Prioritization of NM assessment is needed.
Description:
Find relationships between bioactivities and NM characteristics or testing conditions. Recommend a dose metric for NMs in vitro studies. Establish associations to in vivo toxicity or pathways identified from testing of conventional chemicals with ToxCast HTS methods. May be able to identify structure-activity relationships using physico-chemical properties of NMs.