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Systems biology, adverse outcome pathways, and ecotoxicology in the 21st century
Citation:
EDWARDS, S. W. Systems biology, adverse outcome pathways, and ecotoxicology in the 21st century. Presented at International workshop on Integrative Approaches to Molecular Network Inference, Birmingham, UK, January 31, 2011.
Impact/Purpose:
Expanding this concept to include networks of populations, communities and ecosystems potentially provides a framework for building multi-scale models to predict the effects of chemicals on the environment
Description:
While many definitions of systems biology exist, the majority of these contain most (if not all) of the following elements: global measurements of biological molecules to the extent technically feasible, dynamic measurements of key biological molecules to establish quantitative relationships among them, and experimental designs which perturb the system in specific ways to determine these relationships. This presentation will discuss how these components can be used to develop a model for disease based on an interconnected network of molecular-, cellular-, and organism-level events.