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Society of Toxicologic Pathologists (STP) Annual Symposium General Session II: Modem Pathology Methods for Neural Investigations
Citation:
Hale, S. L., L. Andrews-Jones, W. H. Jordon, B. S. Jortner, R. Boyce, J. T. Boyce, R. T. Switzer III, M. T. Butt, R. H. Garman, K. F. JENSEN, G. Krinke, AND P. B. Little. Society of Toxicologic Pathologists (STP) Annual Symposium General Session II: Modem Pathology Methods for Neural Investigations. TOXICOLOGICAL PATHOLOGY. Society of Toxicology, RESTON, VA, 39(1):52-7, (2011).
Impact/Purpose:
These techniques are covered in more detail in individual manuscripts from each speaker.
Description:
This half-day session at the 20I0 Joint Symposium of the Society of Toxicologic Pathology (STP) and the International Federation of Societies of Toxicologic Pathologists (IFSTP) explored many deceptively simple questions related to toxicologic neuropathology. What is the best method to prepare and adequately sample the nervous system for neuropathology evaluation? What structures or neuroanatomical levels should be sampled? Which special stains and techniques strike the best balance between sensitivity of lesion detection and appropriate allocation of time and money? Perhaps more than any other organ system, accuracy and precision in neuropathological evaluation require careful advance planning, experienced sample handling, appropriate sectioning, and carefule selection of diagnostic techniques. This session focused on processing, sectioning, and staining of both the central (CNS) and peripheral (PNS) nervous systems in both routine (general toxicity) and enhanced (specialized neurotoxicity) studies, and explored modem image analysis techniques and evolving regulatory trends as applied to these processes. These techniques are covered in more detail in individual manuscripts from each speaker. This manuscript has been review according to ORD procedures and approved for publication, such approval does not signify that the contents reflect Agency policy.
