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NHEXAS PHASE I ARIZONA STUDY--STANDARD OPERATING PROCEDURE--COMPENDIUM OF METHOD SUMMARIES FOR COLLECTION AND ANALYSIS OF METALS, PESTICIDE METABOLITES, AND VOC IN BLOOD AND URINE (CDC-COMPENDIUM)
Citation:
Arizona Study Consortium. NHEXAS PHASE I ARIZONA STUDY--STANDARD OPERATING PROCEDURE--COMPENDIUM OF METHOD SUMMARIES FOR COLLECTION AND ANALYSIS OF METALS, PESTICIDE METABOLITES, AND VOC IN BLOOD AND URINE (CDC-COMPENDIUM). U.S. Environmental Protection Agency, Washington, D.C., 1995.
Description:
This compendium includes method summaries provided by the Centers for Disease Control and Prevention/National Center for Environmental Health (CDC/NCEH) for the collection and shipping of blood and urine samples for analysis of metals and volatile organic compounds (VOCs). It provides procedures for urine collection and processing; whole blood collection and processing; testing for pesticide metabolites in urine, metals in blood and urine, and VOCs in blood; interpretation of biomarker measurements; sample storage; and quality assurance and quality control. Keywords: biomarkers; metals; pesticide matabolites; VOCs.
The National Human Exposure Assessment Survey (NHEXAS) is a federal interagency research effort coordinated by the Environmental Protection Agency (EPA), Office of Research and Development (ORD). Phase I consists of demonstration/scoping studies using probability-based sampling designs. The studies collected household environmental and personal samples for chemical analysis, and questionnaires were administered. The NHEXAS Phase I Questionnaires were organized into six modules for simplicity in administration (to minimize respondent burden and maximize participation rates at each step) and for collecting information that can be temporally related to the exposure, concentration, and/or biological measurements collected in NHEXAS: Descriptive, Baseline, Technician, Follow-up, Time and activity diary, and Dietary diary (and follow-up). The NHEXAS Arizona study sampled residences determined by a population-based probability research design for the total population of Arizona and measured metals, pesticides, and volatile organic compounds (VOCs). Analytical results were obtained under strict QA/QC requirements during collection, processing, and final deposition into databases. In addition, strict standard operating procedures were followed throughout the NHEXAS Arizona study. The study was conducted by a consortium composed of the University of Arizona, Battelle Columbus, and the Illinois Institute of Technology. Data collection occurred between June 1995 and February 1998 for the participating households.
NOTE: The U.S. Environmental Protection Agency (EPA), through its Office of Research and Development (ORD), partially funded and collaborated in the research described here. This SOP is part of the Quality Systems Implementation Plan (QSIP) that was reviewed by the EPA and approved for use in the Arizona study and is provided for documentation purposes. It does not reflect EPA methods and should not be construed as such. The methods were generated by the consortium to be used for the NHEXAS pilot study. Mention of trade names or commercial products does not constitute endorsement or recommendation by EPA for use.