You are here:
Mechanisms responsible for the chromosome and gene mutations driving carcinogenesis: Implications for dose-response characteristics of mutagenic carcinogens
Citation:
PRESTON, J. Mechanisms responsible for the chromosome and gene mutations driving carcinogenesis: Implications for dose-response characteristics of mutagenic carcinogens. Edition 1, Chapter 1.1, Greim, H and Albertini, R J (ed.), The cellular response to the Genotoxic Insult. Royal Society of London, London, , 23-32, (2012).
Impact/Purpose:
For a typical DNA-reactive carcinogen that includes both gene and chromosomal mutations, the dose-response curve for the total mutattions will be a linear-quadratic with the form being influenced by the relative proportions of gene and chromosome mutations.
Description:
Through the use of high throughput DNA sequencing techniques, it has been possible to characterize a number of tumor types at the molcular level. This has led to the concept that there are "driver" mutations and "passenger" mutations, with an estimate of the number of the driver mutations being about 120 for all tumors characterized to date.