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Perspectives On The Application Of Mechanistic Information In Chemical Hazard And Dose-Response Assessments
Citation:
U.S. EPA. Perspectives On The Application Of Mechanistic Information In Chemical Hazard And Dose-Response Assessments. U.S. Environmental Protection Agency, Washington, DC, 2010.
Impact/Purpose:
This report summarizes published project results that examined approaches for interpreting observed effects in laboratory animals and their human relevance based on hypothesized modes of action.
Description:
This overview summarizes several EPA Assessment publications reviewing approaches for applying mechanistic information in human health risk assessment and exploring opportunities for progress in this area.
URLs/Downloads:
Perspectives on the Application of Mechanistic Information in Chemical Hazard (Summary Report) (PDF, 4 pp, 44 KB, about PDF)Chen C; Guyton K (2008). Do 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline data support the conclusion of threshold carcinogenic effects? Stoch Environ Res Risk Assess, 22: 487–494.
Guyton K; Barone S; Brown R; Euling S; Jinot J; Makris S (2008). Mode of action frameworks: a critical analysis. J Toxicol Environ Health B Crit Rev, 11: 16-31.
Guyton K; et al (2009). A reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants. Environ Health Perspect, 117: 1664-1672.
Guyton K; et al (2009). Improving prediction of chemical carcinogenicity by considering multiple mechanisms and applying toxicogenomic approaches. Mutat Res Rev Mutat Res, 681: 230-240.
White R; et al (2008). State-of-the-Science Workshop Report: Issues and Approaches in Low Dose-Response Extrapolation for Environmental Health Risk Assessment . Environ Health Perspect.
Woodruff T; et al (2008). Meeting report: moving upstream-evaluating adverse upstream end points for improved risk assessment and decision-making. Environ Health Perspect, 116: 1568-1575.
Record Details:
Record Type:DOCUMENT( SUMMARY)
Product Published Date:09/20/2010
Record Last Revised:10/14/2010
OMB Category:Other
Record ID:
230150