You are here:
Potential For Incorporation Of Genetic Polymorphism Data In Human Health Risk Assessment
Citation:
U.S. EPA. Potential For Incorporation Of Genetic Polymorphism Data In Human Health Risk Assessment. U.S. Environmental Protection Agency, Washington, DC, 2010.
Impact/Purpose:
The work presented in this series of papers focuses on the contribution of genetic polymorphisms to the variability in host metabolism and defense mechanisms by evaluating polymorphisms in 10 enzyme systems including three Phase I metabolic enzymes (CYP2E1, CYP2D6, PON1), four Phase II metabolic enzymes (SULTs, UGTs, GSTs, NATs), and three detoxification enzymes (ALDH2, EH, NQO1).
Description:
This overview summarizes several EPA assessment publications evaluating the potential impact of genetic polymorphisms in ten metabolizing enzymes on the variability in enzyme function across ethnically diverse populations.
URLs/Downloads:
Potential for Incorporation of Genetic Polymorphism Data (Summary Report) (PDF, 7 pp, 62 KB, about PDF)Ginsberg G; Smolenski S; Hattis D; Sonawane B (2002). Population distribution of aldehyde dehydrogenase-2 genetic polymorphism: Implications for risk assessment. Regul Toxicol Pharmacol, 36: 297-309.
Ginsberg G; et al (2009a). The influence of genetic polymorphisms on population variability in six xenobiotic-metabolizing enzymes. J Toxicol Environ Health B Crit Rev, 12: 307-333.
Ginsberg G; et al (2009b). Genetic polymorphism in glutathione transferases (GST): Population distribution of GSTM1, T1, and P1 conjugating activity. J Toxicol Environ Health B Crit Rev, 12: 389-439.
Ginsberg G; et al (2009c). Genetic polymorphism in paraoxonase 1 (PON1): Population distribution of PON1 activity. J Toxicol Environ Health B Crit Rev, 12: 473-507.
Ginsberg G; et al (2010). Genetic polymorphism in metabolism and host defense enzymes: implications for human health risk assessment. Crit Rev Toxicol, 40(7):575-619.
Neafsey P; Ginsberg G; Hattis D; Sonawane B (2009a). Genetic polymorphism in cytochrome P450 2D6 (CYP2D6): Population distribution of CYP2D6 activity. J Toxicol Environ Health B Crit Rev, 12: 334-361.
Neafsey P; Ginsberg G; Hattis D; Johns DO; Guyton KZ; Sonawane B (2009b). Genetic polymorphism in CYP2E1: Population distribution of CYP2E1 activity. J Toxicol Environ Health B Crit Rev, 12: 362-388.
Walker K; et al (2009). Genetic polymorphism in N-acetyltransferase (NAT): population distribution of NAT1 and NAT2 activity. J Toxicol Environ Health, 12(5-6):440-72.