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Fundamental concepts, current regulatory design and interpretation
Citation:
DASTON, G. P. AND T. B. KNUDSEN. Fundamental concepts, current regulatory design and interpretation . Second Edition, Chapter 12, Kudsen, T., Daston, GP (ed.), Comprehensive Toxicology. Elsevier Ltd, Oxford, Uk, 12:3-9, (2010).
Impact/Purpose:
It will be possible to determine the relevance of animal models to assess the toxicity of each chemical and to use mechanistic information to design better models to predict human responses. It should be possible with pharmacokinetic modeling to derive better experimental designs and facilitate interpretation of developmental toxicity studies.
Description:
Developmental toxicology became a formalized field about 50 years ago. Over this time, it has evolved from a largely observational science to one that is highly mechanistic in nature. Our increasing knowledge of mechanism of action, coupled with techniques that facilitate the generation and interpretation of large data sets will fundamentally change our approach to identifying developmental hazards. It will be possible to screen for developmental toxicants based on evaluating the molecular targets with which they interact and the physiological states they perturb, rather than evaluating outcomes at the organ and organism level.
