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Recommendations for Developing Alternative Test Methods for Screening and Prioritization of Chemicals for Developmental Neurotoxicity
Citation:
CROFTON, K. M., W. R. MUNDY, P. J. Lein, A. Bal-Price, S. Coecke, A. Seiler, H. Knaut, L. Buzanska, AND A. Goldberg. Recommendations for Developing Alternative Test Methods for Screening and Prioritization of Chemicals for Developmental Neurotoxicity. ALTEX. Society ALTEX Edition, Kuesnacht, Switzerland, 28(1):9-15, (2011).
Impact/Purpose:
This document provides recommendations for developing alternative DNT approaches that will generate the type of data required for evaluating and comparing predictive capacity and efficiency across test methods and laboratories.
Description:
Developmental neurotoxicity testing (DNT) is perceived by many stakeholders to be an area in critical need of alternative methods to current animal testing protocols and gUidelines. An immediate goal is to develop test methods that are capable of screening large numbers of chemicals. Alternative DNT methods will require demonstration of their predictive capacity and improved efficiency in terms of time and expense. This document provides recommendations for developing alternative DNT approaches that will generate the type of data required for evaluating and comparing predictive capacity and efficiency across test methods and laboratories. These recommendations were originally drafted to stimulate and focus discussions of alternative testing methods and models for DNT at the TestSmart DNT II meeting (http://caat.jhsph.edu/dnt2/) and this document reflects critical feedback from all stakeholders that participated in this meeting. The intent of this document is to serve as a catalyst for engaging the research community in the development of DNT alternatives and it is expected that these recommendations will continue to evolve with the science.
