Description:

OncoLogic^TM - A Computer System to Evaluate the Carcinogenic Potential of Chemicals
OncoLogic^TM is a software program that evaluates the likelihood that a chemical may cause cancer. OncoLogic^TM has been peer reviewed and is being released by EPA at no cost, to be available to any researcher or organization wishing to evaluate cancer potential of chemicals. This expert system is a computer program that mimics the judgment of experts by following sets of knowledge rules that are based on studies of how chemicals cause cancer in animals and humans. An expert system, like OncoLogic^TM, asks for chemical and use information from the user and following the knowledge rules incorporated into the system, uses the responses to construct an estimation of the most likely results. Currently OncoLogic^TM has subsystems that can evaluate fibers, metals, polymers, and more than 48 classes of organic chemicals.

Record Details:

Record Type:MODEL

Record Released:07/02/2010

Record Last Revised:07/02/2010

Record ID: 225846

Show Additional Record Data

Model Detail:

Model Evaluation :OncoLogic^TM was peer reviewed at the developmental stage by external domain experts and, after completion of versions 2.0 and 4.0, by two international peer review panels of domain experts. In addition, the scientific basis of the rule packages for a number of classes of chemicals were published in peer-reviewed open literature. The OncoLogic^TM team also participated in an international prospective predictive exercise sponsored by NTP to evaluate the capabilities of various methods to predict the outcome of cancer bioassays several years before the studies were completed. In the first exercise, focusing on 1 of 8 aromatic amines, OncoLogic^TM achieved a high degree of accuracy. In the second exercise on 30 chemicals of diverse structure, the OncoLogic^TM approach was rated as one of the best performers (Benigni, R, Zito, R: The 2nd NTP Comparative Exercise on the Prediction of Rodent Carcinogenicity: Definitive Results, Mutat. Res. 566, 49, 2004). In addition, a separate external validation of OncoLogic^TM performed by the FDA Food Additives Division (Mayer et al., SAR analysis tool: validation and applicability in predicting carcinogens. Regul. Toxicol. Pharmacol. 50: 50, 2008) showed accuracy of 91% overall for all chemicals of interest, and 96% accuracy for those carcinogens of highest concern within the validation exercise.

Model URL :http://www.epa.gov/oppt/sf/pubs/oncologic.htm

Model Guidance Documents :OncoLogic^TM Users Manual (2010). Risk Assessment Division (7403), Office of Pollution Prevention and Toxics, U.S. Environmental Protection Agency, 1200 Pennsylvania Ave., N.W., Washington, DC 20460. Available at: http://www.epa.gov/oppt/sf/pubs/UserManual.pdf

Model Download Information :Included in the installer are the Quick Start Tutorial and the OncoLogic^TM User Guide, which are also posted below for separate download.
http://www.epa.gov/oppt/sf/pubs/oncologic.htm

modelcontactinfo :Agency Contact:
Dr. Yintak Woo, U.S. EPA
Office of Chemical Safety and Pollution Prevention
Risk Assessment Division
U.S. Environmental Protection Agency
1200 Pennsylvania Avenue, NW
Washington, DC 20460-0001
Phone: 202-564-7603
email: woo.yintak@epa.gov

Model Inputs :Inputs are chemical class dependant. May include: structure (including subunits present), physical/chemical properties (stability, etc.), biological and mechanistic information, as well as possible routes of exposure

Model Outputs :The output from OncoLogic^TM is a justification report consisting of two parts: a summary of the evaluation and a line of reasoning (justification) of how the final conclusions were derived. Within the summary section, a final level of concern is stated along with any other messages that merit special attention. The concern levels used by the OncoLogic^TM system are qualitative terms used by the U.S. EPA Structure Activity Team (SAT) for ranking the hazard levels of chemicals. The specific terms in order from highest concern to lowest concern are: HIGH, HIGH-MODERATE, MODERATE, LOW-MODERATE, MARGINAL, LOW. The line of reasoning part of the justification report keeps track of the rules that are used to arrive at a level of concern. The line of reasoning is specific to each evaluation and represents the actual rules used for the particular compound. The line of reasoning section also will draw attention to special considerations flagged for the compound, but in further detail than the summary section.

otheruserdocs :

• OncoLogic^TM Quick Start Tutorial (PDF) (50 pp, 1.15MB)
• OncoLogic^TM: Frequently Asked Questions (PDF) (6 pp, 260 KB)
• Running the model(PDF) (10 pp, 144K)
• Interpreting results (PDF) (1 p, 46K)
• OncoLogic^TM Cancer Assessment Presentation for SF Program (PDF) (51 pp, 332 KB)

Model Computer Requirements:

Model Operating Systems Needs :Microsoft Windows 95 or later (including 98, ME, NT, XP and Vista).

Model Hardware Needs :Minimum requirements are an IBM-compatible computer with an 80386 or 80286 processor and 640 KB RAM. At least 512 to 550 KB RAM must be free for acceptable performance, and expanded memory will improve performance.

other_req :N/A