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IRIS Toxicological Review of Trichloroethylene (Interagency Science Consultation Draft)
As per the May 21, 2009, IRIS process, all comments received from federal agencies and White House offices on draft IRIS assessments will be made publicly available. Accordingly, interagency comments and the interagency draft of the Trichloroethylene IRIS assessment have been posted on this site.
Citation:
U.S. EPA. IRIS Toxicological Review of Trichloroethylene (Interagency Science Consultation Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/011C, 2009.
Impact/Purpose:
The purpose of this Toxicological Review is to provide scientific support and rationale for the hazard and dose-response assessment in IRIS pertaining to chronic exposure to trichloroethylene. It is not intended to be a comprehensive treatise on the chemical or toxicological nature of trichloroethylene.
Description:
On November 3, 2009, the Toxicological Review of Trichloroethylene and the charge to external peer reviewers were released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments and the interagency science consultation draft of the IRIS Toxicological Review of Trichloroethylene and the charge to external peer reviewers are posted on this site.
URLs/Downloads:
Toxicological Review of Trichloroethylene (Interagency Science Consultation Draft) (PDF, 1255 pp, 4833 KB, about PDF)Charge to External Peer Reviewers (Interagency Science Consultation Draft) (PDF, 4 pp, 34 KB, about PDF)
Appendix A: PBPK Modeling of TCE and Metabolites – Detailed Methods and Results (PDF, 108 pp, 1474 KB, about PDF)
Appendix B: Systematic Review of Epidemiologic Studies on Cancer and Trichloroethylene (TCE) Exposure (PDF, 348 pp, 1577 KB, about PDF)
Appendix C: Meta-analysis of Cancer Results from Epidemiological Studies (PDF, 71 pp, 410 KB, about PDF)
Appendix D: Neurological Effects of Trichloroethylene (PDF, 136 pp, 937 KB, about PDF)
Appendix E: ANALYSIS OF LIVER AND CO-EXPOSURE ISSUES FOR THE TCE TOXICOLOGICAL REVIEW (PDF, 396 pp, 1674 KB, about PDF)
Appendix F: TCE Non-Cancer Dose-Response Analyses (PDF, 40 pp, 419 KB, about PDF)
Appendix G: TCE Cancer Dose-Response Analyses with Rodent Cancer Bioassay Data (PDF, 41 pp, 894 KB, about PDF)
Appendix H: Lifetable Analysis/Equations Used for Weighted Linear Regression of Results from Charbotel et al. (2006) (PDF, 4 pp, 173 KB, about PDF)
Appendix Linked Files (zip, 90 MB)
USDA Comments on the review of Trichloroethylene (PDF, 2 pp, 27 KB, about PDF)
OMB Comments on the review of Trichloroethylene (PDF, 2 pp, 38 KB, about PDF)
ATSDR Comments on the review of Trichloroethylene (PDF, 1 pp, 13 KB, about PDF)
NASA Comments on the review of Trichloroethylene (PDF, 8 pp, 131 KB, about PDF)
DoD Comments on the review of Trichloroethylene (PDF, 72 pp, 436 KB, about PDF)
DoD Comments on the Charge Questions (PDF, 4 pp, 36 KB, about PDF)