Citation:

Luque, R., B. Baruwati, AND R. S. VARMA. Magnetically separable nanoferrite-anchored glutathione: Aqueous homocoupling of arylboronic acids under microwave irradiation. GREEN CHEMISTRY. Royal Society of Chemistry, Cambridge, Uk, 12(9):1540-1543, (2010).

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To inform the public.

Description:

A highly active, stable and magnetically separable glutathione based organocatalyst provided good to excellent yields to symmetric biaryls in the homocoupling of arylboronic acids under microwave irradiation. Symmetrical biaryl motifs are present in a wide range of natural products which have interesting properties including antivirals, polymers and ligands employed in catalysis. This important family of compounds can be synthesized by a number of organic protocols including the Suzuki and Sonogashira cross coupling reactions, as well as their homocoupling alternatives. Both types of reactions have generally been reported to be catalysed with a variery of supported transition metal and/or transition metal complexes (mostly palladium) and oxidants under base conditions in a range of solvents., More recently, Fe has joined the roadmap of catalysts employed with such purposes and reports of iron catalysed Suzuki and Sonogashira protocols as well as related C-N and three-component couplings have recently been described. However, the effect of impurities of other metals including palladium in these systems have created the need of further investigations to prevent metal-trace contaminant catalysed processes.

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