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Development of In Vitro Assays to Assess Chemicals and Environmental Samples for Thyroid Hormone Synthesis Inhibition
Citation:
BURGESS, E. M., M. MILLS, AND M. W. HORNUNG. Development of In Vitro Assays to Assess Chemicals and Environmental Samples for Thyroid Hormone Synthesis Inhibition . Presented at 2010 Midwest SETAC, St. Paul, MN March 24-26, 2010, St. Paul, MN, March 24 - 26, 2010.
Impact/Purpose:
The results can provide information to make prioritization decisions for chemicals for further testing in vivo.
Description:
This abstract presents research being conducted at MED under the Safe Pesticides/Safe Products and Endocrine Disrupting Chemicals research area. The research described herein is in response to the mandate to the Agency to develop a research program to evaluate the potential adverse effects of chemicals on vertebrate endocrine systems including thyroid hormones. The results are presented in the context of the development of shorter term in vitro and ex vivo assays that can be used to screen chemicals and environmental samples for thyroid activity. The results can provide information to make prioritization decisions for chemicals for further testing in vivo. In addition, if these assays identify the presence of potential thyroid disrupting chemicals in surface waters or other environmental samples, these can then be further analyzed to identify what specific chemicals are responsible for this activity.