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Linking Mass Spectrometry with Toxicology for Emerging Water Contaminants
Citation:
RICHARDSON, S. D. Linking Mass Spectrometry with Toxicology for Emerging Water Contaminants. Presented at 58th ASMS Conference on Mass Spectrometry and Allied Topics, Salt Lake City, UT, May 23 - 27, 2010.
Impact/Purpose:
see description
Description:
This overview presentation will discuss the benefits of combining mass spectrometry with toxicology. These benefits will be described for 3 main areas: (1) Toxicity assays used to test new environmental contaminants previously identified using mass spectrometry, such that further quantitative MS methods development is focused on those contaminants that pose the greatest toxicological risk; (2) Toxicity used in conjunction with mass spectrometry, such that fractions (size or polarity) are collected and tested for toxicity, and toxicity results are used to focus MS identification efforts on the most toxic fractions; and (3) Toxicity assays used to test environmental degradation products or treatment products of specific contaminants identified using mass spectrometry, such that the risk of the degradation/reaction products can be determined. Examples will be given for drinking water DBPs (regarding fractionation and toxicity testing helping to focus further measurement and formation research) and for other emerging contaminants, such as pharmaceuticals (for determining whether an environmental degradation product or a reaction product formed by ozone in drinking water treatment retains the toxicity of the parent compound). Integrated toxicology-mass spectrometry research is expected to provide meaningful results for addressing public health and regulatory issues.
URLs/Downloads:
RICHARDSON 10 014 ASMS ABSTRACT.PDF (PDF, NA pp, 11 KB, about PDF)RICHARDSON 10 014A_ASMS-2010.PDF (PDF, NA pp, 1017 KB, about PDF)